PF-06446846 hydrochloride( —— )

Catalog No. M33462 CAS No. 1632250-50-0

PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

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Size	Price / USD	Stock	Quantity
2MG	138	Get Quote
5MG	215	Get Quote
10MG	345	Get Quote
25MG	546	Get Quote
50MG	780	Get Quote
100MG	1053	Get Quote
500MG	2097	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

PF-06446846 hydrochloride
Note

Research use only, not for human use.
Brief Description

PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.
Description

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochlorideinhibits PCSK9 by inducing the ribosome to stall around codon 34.
In Vitro

PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM.
In Vivo

PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.Animal Model:Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)Dosage:5, 15, and 50 mg/kg Administration:Oral gavage; daily for 14 daysResult:Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1632250-50-0
Formula Weight
Molecular Formula

C22H20CIN7O.XHCl
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (531.52 mM; Ultrasonic ) H2O : 100 mg/mL (212.61 mM; Ultrasonic)
SMILES

Cl.Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882.?

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